Interestingly, the final differentiation of both T and B cells involves a BLIMP1-independent clonal-expansion phase, followed by the production of short-lived effector cells that require BLIMP1 to ...

These findings suggest that KIR2DS2-positive (KIR2DS2+) natural killer (NK) cells could be an attractive therapeutic target ...

Inter-organelle communication via the formation of membrane contact sites (MCS) is essential for cell homeostasis. Bacterial pathogens residing in membrane bound vacuoles have exploited this ...

The CAR-T cell therapy Carvykti has been shown to be effective among patients outside the confines of a clinical trial.

Umoja Biopharma, Inc. (Umoja), a transformative immunotherapy company creating off-the-shelf treatments that aim to extend the reach and effectiveness of CAR-T cell therapies in oncology and ...

Discover a breakthrough study that has reported encouraging outcomes using autologous chimeric antigen receptor T cells in ...

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding ...

two antibodies that, similar to tumor antigens presented by an antigen-presenting cell (APC) of the immune system, stimulate CAR-T cells to differentiate into tumor cell-killing “effector T ...

ALTB-268 demonstrated its anti-inflammatory effect in an acute colitis hPSGL-1 mouse model.The data confirmed that ALTB-268 acts as an immune ...