10月11日，CDE官网显示，恒瑞医药的EZH2抑制剂SHR2554片申报上市。这是首个申报上市的国产EZH2抑制剂。 SHR2554是恒瑞医药自主研发的新型、高效、选择 ...

Histone methylation (H3K36me3 barrier) by NSD2 promotes the functions of genes involved in cell proliferation. NSD2 decreases in senescent cells, which causes altered epigenome and gene expression ...

Aberrant expression of G9a and NSD2 has been identified in multiple types of cancer. Therefore, dual-target inhibitors blocking both pathways may be considered a potential strategy to treat solid ...

The NSD2 enzyme acts to prevent cell aging. LEFT: Suppression of the NSD2 gene in fibroblasts arrested cell proliferation. RIGHT: Suppression of the NSD2 gene induces senescent cells with SA-?- ...