The carbohydrate-binding receptor dectin-1 is an example of a CLR that can do both. Strong immune responses to fungus-derived β-glucans, a PAMP expressed by fungal pathogens, require dectin-1 ...
Iwakura has also clarified the roles of an immune receptor, dectin-1, implicated in host defence against fungal infection. Also, inhibition of its signalling in healthy individuals suppresses ...