Recent structures of the Runx1–CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA.

Proteins or small molecules designed to bind certain DNA sequences and to regulate target genes have much promise in both basic and applied research. But it is important that these tools be specific.

The use of antibodies with a fluorescent tag against BrdU makes it possible to determine S phase if cells were pulsed with 10uM BrdU more accurately then just using DNA binding dyes such as PI, 7-AAD, ...

The Cell Cycle Kit utilizes a DNA binding dye to enable the creation of a cell cycle profile and the quantification of the relative percentage of cells in each phase of the cell cycle. Key ...