Red arrows indicate the DNA repair pathways that are known to aid bacterial ... RecBCD, Recombinase BCD; RuvC, recombination ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks ... This intermediate shows a mini filament, with its nine RecA proteins in gold and its single-stranded DNA in ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

This knowledge came primarily from traditional biochemical assays, which identify the molecules that bind to DNA during repair, but cannot explain the intermediate and dynamic protein activity ...

The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...

Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

"Our biochemical analysis with purified BRCA1 protein helps illuminate ... mechanism (homologous recombination, HR). BRCA1 acts to channel DNA breaks into HR for repair, Burma said.

Meiotic recombination ... ssDNA-binding protein, Replication protein A (RPA), to protect these ssDNAs from nucleolytic ...

Research led by The University of Texas Health Science Center at San Antonio shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes ...

The main focus is recombination mediator proteins (RMPs), which are essential for genome stability and DNA repair in all organisms.

DNA repair and recombination pathways, chromosome structure, genome sequencing technologies and the analysis of sequence data to study protein/DNA interactions, chromosome interactions and DNa ...

"Our biochemical analysis with purified BRCA1 protein helps illuminate ... mechanism (homologous recombination, HR). BRCA1 acts to channel DNA breaks into HR for repair, Burma said.