Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs ... This intermediate shows a mini filament, with its nine RecA proteins in gold and its single-stranded ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters ... Recombinase A; RecBCD, ...

This knowledge came primarily from traditional biochemical assays, which identify the molecules that bind to DNA during repair, but cannot explain the intermediate and dynamic protein activity ...

It is thought that these flanking segments mediate the binding of mammalian DNA ligases to other proteins involved in DNA replication, repair, and recombination. The mammalian isozymes are referred to ...

"Our biochemical analysis with purified BRCA1 protein helps illuminate ... mechanism (homologous recombination, HR). BRCA1 acts to channel DNA breaks into HR for repair, Burma said.

Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

Our lab studies the mechanism of protein function at the atomic resolution level utilizing X-ray crystallography and biochemical approaches. The main focus is recombination mediator proteins (RMPs), ...

Meiotic recombination ... ssDNA-binding protein, Replication protein A (RPA), to protect these ssDNAs from nucleolytic ...

Research led by The University of Texas Health Science Center at San Antonio shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes ...

"Our biochemical analysis with purified BRCA1 protein helps illuminate ... mechanism (homologous recombination, HR). BRCA1 acts to channel DNA breaks into HR for repair, Burma said.

The topics covered in the module include experimental approaches to address the function of specific genes, mechanisms of regulated gene expression, DNA repair and recombination pathways, chromosome ...