Skeletal muscle tissue demonstrates global hypermethylation with aging. However, methylome changes across the time-course of ...

DNA hypermethylation in tumorigenesis: Epigenetics joins genetics. Trends Genet. 16, 168–174 (2000). 【关于投稿】 转化医学网（360zhyx.com）是转化医学核心门户 ...

Hypermethylation of CpG islands can cause tumors by shutting off tumor-suppressor genes. In fact, these types of changes may be more common in human cancer than DNA sequence mutations (Figure 2).

Epigenetic alterations come in many forms; the most frequently examined and best understood is DNA methylation (DNAm). DNAm occurs by the addition of a methyl group onto a cytosine-phosphate-guanine ...

Andrew Feinberg, the Bloomberg Distinguished Professor of Biomedical Engineering at Johns Hopkins University, has been ...

As an oncometabolite, R-2-HG induces malignant transformation of glial progenitor cells by altering the chromatin structure (through broad DNA and histone hypermethylation) and disrupting the ...