Where and when do cyclins act on the cell cycle? (A) Cycling cells undergo three major transitions during their cell cycle. The beginning of S phase is marked by the onset of DNA replication ...

Since, the discovery in the seventies and eighties of the core machinery regulating the eukaroytic cell cycle, the cyclin-dependent kinases (cdks) and cyclins, the cell-cycle field has grown ...

Cyclins and cyclin-dependent kinases (CDKs) regulate the activity of E2F and Rb to drive cell cycle progression. Disrupting this interaction has shown lethality in cancer cells harboring alterations ...

cranberries and their extracts have been shown to reduce the amount of proteins called cyclins in prostate cancer cells.

cells that have exited the cell cycle, retain their capacity to re-enter when necessary. In the past, this labs study of G1 cyclins and the Kip family of cdk inhibitors contributed greatly to our ...

Circle Pharma is focusing its development efforts on cyclins, which are master regulators of the machinery that controls the progression of cells through the cell cycle and are key drivers in many ...

We have focused on investigating the regulation and function of D-type cyclins in splenic B-2 and peritoneal B-1a cells in response to B-cell antigen receptor engagement. Effort has also been directed ...