Since, the discovery in the seventies and eighties of the core machinery regulating the eukaroytic cell cycle, the cyclin-dependent kinases (cdks) and cyclins, the cell-cycle field has grown ...

For most proteins, these two opposing processes are dynamically balanced during the cell cycle, holding each protein at a constant (steady state) level. For some proteins (for example, cyclins ...

Cyclins and cyclin-dependent kinases (CDKs) regulate the activity of E2F and Rb to drive cell cycle progression. Disrupting this interaction has shown lethality in cancer cells harboring alterations ...

We have focused on investigating the regulation and function of D-type cyclins in splenic B-2 and peritoneal B-1a cells in response to B-cell antigen receptor engagement. Effort has also been directed ...