Further investigation is required to clarify this putative cell-cycle connection. Interestingly, the other key players of the RB–E2F pathway, such as D-type cyclins, CDK-inhibitory proteins (ICK ...

Since, the discovery in the seventies and eighties of the core machinery regulating the eukaroytic cell cycle, the cyclin-dependent kinases (cdks) and cyclins, the cell-cycle field has grown ...

Cyclins and cyclin-dependent kinases (CDKs) regulate the activity of E2F and Rb to drive cell cycle progression. Disrupting this interaction has shown lethality in cancer cells harboring alterations ...

Circle Pharma is focusing its development efforts on cyclins, which are master regulators of the machinery that controls the progression of cells through the cell cycle and are key drivers in many ...