Cell-cycle re-initiation also occurs in less natural situations, such as during the regeneration ... by overexpression of cyclin, the threshold level of CDK activity below which cells exit the ...

For most proteins, these two opposing processes are dynamically balanced during the cell cycle, holding each protein at a constant (steady state) level ... of Cdk–cyclin complexes, Cdk activity ...

resulted in elevated cyclin A2 levels and in increased proliferation (fold increase in cell count within 48 h, 3.9 ± 0.4 vs. 1.5 ± 0.2 in controls, P < 0.05) of Min6 cells (Supplemental Fig.

Poster presentation details are below: Author: Molina et al Title: CID-078, a first-in-class oral cyclin A/B-RxL inhibitor ... alterations that cause cell cycle dysregulation.