The viral cyclin encoded by Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) facilitates both cell-cycle progression and apoptotic cell death. Although they seem a paradoxical pair, the cell ...

Cell-cycle exit is correlated with a decrease in cyclin-dependent kinase (CDK) activity. The molecular mechanisms by which differentiation and CDK activity interconnect are poorly understood.

Exendin-4 stimulates an early (2-4 h) increase in cyclin A2, whereas PDX-1 transcript increases after 6-8 h. Densitometric analysis of relative protein levels normalized to actin at corresponding ...

Poster presentation details are below: Author: Molina et al Title: CID-078, a first-in-class oral cyclin A/B-RxL inhibitor ... alterations that cause cell cycle dysregulation.