It is important that both the DNA and its chromatin are copied accurately to ensure young and healthy cells. Problems with ...

Researchers have identified a key weakness in acute myeloid leukemia, offering a promising new strategy to delay the ...

Because so many diseases, such as cancer ... HDACs are enzymes that remove the acetyl groups from DNA, which condenses chromatin and stops transcription. Blocking this process with HDAC inhibitors ...

Researchers developed MethylGPT, a powerful transformer-based model that identifies DNA methylation patterns, enabling ...

A new study led by Harvard Medical School researchers shed new light on how even a single defective copy of the ...

Cell-free DNA can be used for non-invasive cancer detection and disease monitoring to enhance personalized medicine.

The Mattiroli group's researchers discovered that the speed at which DNA is replicated during cell division can be directly ...

The proper folding of the chromatin structure plays a crucial role in the regulation of genomic DNA functions, its disruption leading to various diseases. Therefore, understanding the chromatin ...

This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to reveal mechanisms of disease. Our laboratory works at the intersection of three fields: ...

These findings, published in Molecular Cell, may help scientists to find therapies and medicines for diseases such as cancer in the future. Chromatin as a guide Every day, our cells divide. Each time ...