The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

Researchers have identified a key weakness in acute myeloid leukemia, offering a promising new strategy to delay the ...

Cell-free DNA can be used for non-invasive cancer detection and disease monitoring to enhance personalized medicine.

The proper folding of the chromatin structure plays a crucial role in the regulation of genomic DNA functions, its disruption leading to various diseases. Therefore, understanding the chromatin ...

This opens up new doors to study how the copying of the DNA and its packaging are linked. These findings, published in Molecular Cell, may help scientists to find therapies and medicines for diseases ...

Researchers developed MethylGPT, a powerful transformer-based model that identifies DNA methylation patterns, enabling ...

The Mattiroli group's researchers discovered that the speed at which DNA is replicated during cell division can be directly ...

We specialize in high throughput top down liquid chromatography-mass spectrometry. This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to ...

Aug;42(8):1282-1295. Mitra S, Malik R, Wong W, Rahman A, Hartemink AJ, Pritykin Y, Dey KK, Leslie CS. 2024. Single-cell multi-ome regression models identify functional and disease-associated enhancers ...