Explorations of toxic protein ... and some of its abnormal forms may be toxic; this has been termed a 'subversion of function'. If so, PrP C contributes to neurotoxicity in prion disease but ...

In these mice the biological characteristics of different ... The first is that the active component in prions is an abnormal protein called prion protein (abbreviated PrP). Normal animal cells ...

A recent paper reported the in vitro generation of new prion strains, supporting the idea that 'strain-ness' is encoded in the protein structure ... humans. The characteristic promiscuity of ...

A prime example of proteins that catalyze their own conformational change into the toxic form is the prion proteins ... in all these diseases is an abnormal tendency of proteins to aggregate ...

which produces a so-called prion protein. Prions are misfolded versions of normal proteins, and their abnormal shape is toxic to cells in the body, particularly neurons in the brain. One of the ...