In the present work, the degree of centrosome amplification was quantified by immunofluorescence microscopy. We ranked tumors by their degree of centrosome amplification, and genes whose ...

For almost a century, our understanding of the tiny structure at the centre of the cell called the centrosome was limited to its ability to organize mitotic spindles and other microtubule arrays.

The resulting cells, locked together like Siamese twins, would have twice as many chromosomes and centrosomes, making them unfit and prone to malignancy. Many cancer cells, for example ...