Only this time the antigen is whole and B cells don't keep it to themselves. The BCR- and TCR-mediated immunological synapses are strikingly similar in terms of antigen receptor recruitment ...

Antigenic stimulation mediated by the B-cell receptor (BCR) regulates survival, proliferation and migration processes in B-CLL, thus suggesting a prominent role in B-CLL pathogenesis and progression.

Figure 4: Impaired antigen receptor–activated B cell proliferation and humoral responses in Vav-deficient mice. Figure 5: Vav-2 in BCR signaling and tyrosine phosphorylation in Vav-1 −/− Vav ...

In patients failing on B-cell receptor (BCR) inhibitors, 72% of patients taking venetoclax are yet to have their disease progress after 12 months. In patients with previously treated CLL and 17p ...