These risks seem to be greatest for a group of NSAIDs called “COX-2 inhibitors,” but neither Aleve nor Advil is this type.

Aleve is an NSAID, and it blocks the COX enzymes (called COX-1 and COX-2) that the body uses to make prostaglandins. This, in turn, acts on inflammation by limiting the body's ability to produce ...

Naproxen sodium 220mg, diphenhydramine HCl 25mg; caplets. Avoid concomitant other pain relievers. Naproxen may decrease effects of aspirin. Increased risk of GI bleed with anticoagulants ...

Naproxen sodium 220mg, pseudoephedrine HCl 120mg; ext-rel tabs; contains sodium 22mg/caplet. Hypertensive crisis with MAOIs (see Contraindications). β-blockers may increase pressor effects of ...