The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central regulator of various cellular ...
Non-transformed cells depend on growth factor signaling to direct glucose and glutamine uptake ... Cell lines exhibiting aerobic glycolysis are glucose-dependent because the PI3K/Akt/TOR pathway ...
We also found that tumor growth induces overly activated regulatory T (Treg) cells with their CTL suppressor function titratable along the PI3K-Akt-Foxo1 signaling pathway to overcome cancer immune ...