No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have ...

An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...

To achieve this, non-muscle myosin 2 forms higher-order filaments within the cell, which then interact with the actin cytoskeleton network to apply force and produce movement. Until recently, the ...