No biological system has been studied by more diverse approaches than the actin-based molecular motor myosin. Biophysics, biochemistry, physiology, classical genetics and molecular genetics have ...
An individual sarcomere contains many parallel actin (thin) and myosin (thick) filaments. The interaction of myosin and actin proteins is at the core of our current understanding of sarcomere ...
To achieve this, non-muscle myosin 2 forms higher-order filaments within the cell, which then interact with the actin cytoskeleton network to apply force and produce movement. Until recently, the ...
The work builds on groundbreaking discoveries related to the F-actin network that Fowler has made throughout her 40-year career. As a post-doctoral fellow Fowler was the first to discover myosin in ...
Muscle fibers in children with SMA type 1 show substantial differences in components of the myosin protein called heavy ...